Runeword: Prudence - Horadric Cube recipe - Diablo IV Season 15

The Runeword: Prudence recipe in the Diablo IV Horadric Cube takes 1x Common (white/gray) base item of the listed type + 1x Mal rune + 1x Tir rune and produces Prudence (Unique-quality runeword item).

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runewordHidden recipeeternalNew in Season 15

Rune order: Mal Tir. Key effects (one guide client data, some values shown as ranges/placeholders in the source): +500 all resistance, 10% damage reduction, Indestructible. Discovered 2026-09-16 by streamer DiEoxidE ('Stealth') via datamining/testing - not in official patch notes. 84 total item variants exist across all 19 runewords x compatible base types x normal/Ancestral.

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