Runeword: Grief - Horadric Cube recipe - Diablo IV Season 15

The Runeword: Grief recipe in the Diablo IV Horadric Cube takes 1x Common (white/gray) base item of the listed type + 1x Eth rune + 1x Tir rune + 1x Lo rune + 1x Mal rune + 1x Ral rune and produces Grief (Unique-quality runeword item).

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runewordHidden recipeeternalNew in Season 15

Rune order: Eth Tir Lo Mal Ral. Key effects (one guide client data, some values shown as ranges/placeholders in the source): +750-1000 weapon damage, Indestructible, 40% poison damage. Discovered 2026-09-16 by streamer DiEoxidE ('Stealth') via datamining/testing - not in official patch notes. 84 total item variants exist across all 19 runewords x compatible base types x normal/Ancestral.

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