The Legacy Rune Upgrade: Ist x2 + Flawless Ruby -> Vex recipe in the Diablo IV Horadric Cube takes 2x Ist rune + 1x Flawless Ruby and produces Vex rune.
runeHidden recipeseasonalNew in Season 15
One of 14 hidden Legacy Rune upgrade recipes discovered in S15 (patch 3.2.1 client data via one guide). Part of the 'long ladder' (Tir->Eth->Ith->Tal->Ral->Ort->Thul->Amn->Sol, 3-per-step) or 'short ladder' (Mal->Ist->Vex->Ohm->Lo->Ber->Jah, 2-per-step); the two ladders are NOT linked (no Sol-to-Mal recipe). Hidden recipe. Gem requirement (Flawless Ruby) is SINGLE-SOURCE (another guide only, re-fetched directly on 2026-09-19 and confirmed present on the page verbatim); one guide client-data lists only the rune count for this ladder, no gem. Treat gem requirement as unconfirmed/disputed. NOTE: Thul, Vex, Ohm, and Jah are described by one guide as pre-existing D4 runes (not new S15 drops) reused here as ladder rungs - see the 'Legacy Runes' material entry for a flagged naming-overlap concern with the base game's own Legendary Rune Crafting outputs of the same names.
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