Locran's Talisman is a Unique Amulet in Diablo IV Season 15 for All classes. It comes from General Unique Pool; General Unique Pool - every Lair Boss (Initiate, Greater, Exalted, Belial) can drop it in addition to their dedicated table (one guide's Boss Loot Table Cheat Sheet).
Unique power
Critical Strikes deal [80 - 100]%[x] increased damage but your Critical Strike Chance is reduced by 50%[+].
Affixes
Primary Core Stat
Critical Strike Damage Multiplier
Where it drops
General Unique Pool
General Unique Pool - every Lair Boss (Initiate, Greater, Exalted, Belial) can drop it in addition to their dedicated table (one guide's Boss Loot Table Cheat Sheet)